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Ascorbyl Tetraisopalmitate

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Ascorbyl Tetraisopalmitate (ATIP or branded VC-IP) is the tetraester of ascorbic acid and isopalmitic acid. It is a clinically proven, stable, oil-soluble vitamin C derivative that provides superior percutaneous absorption and effectively converts to free vitamin C in the skin. This multi-functional ingredient inhibits the activity of intracellular tyrosinase and melanogenesis to brighten, reduces UV-induced cell + DNA damage, provides potent antioxidant functionality, and boosts collagen synthesis.

It is often cited that ATIP and tetrahexyldecyl ascorbate (THDA) are two names for the same thing, but this is in error. They indeed have many similarities, including the same molecular weight, but they are each their own unique chemical.1

chemical structure Ascorbyl Tetraisopalmitate (ATIP) vs. Tetrahexyldecyl Ascorbate (THDA)

As you can see, the chemical structure of ATIP has bent arms while THDA’s reach out long and straight. These bent arms make ATIP quite a bit more expensive to produce and may have impacts on function, such as skin permeability. Another bonus of ATIP is its extensive efficacy data showing impressive results even at low usage levels, where THDA is not quite as well studied. That said, both oil-soluble forms are likely excellent vitamin C actives in thier own right.1

Here are some impressive Ascorbyl Tetraisopalmitate benefits backed by science:

  • Remains in the skin cells forty to eighty times longer than L-ascorbic acid and will have as much as four times the effect2
  • Allows for faster percutaneous absorption than other forms of vitamin C3—cells absorb 10 times the concentration of ATIP compared to L-ascorbic acid (manufacturer’s study)
  • Is a proven precursor of Vitamin C and effectively suppresses UVB-induced skin pigmentation4
  • Reduces trans-epidermal water loss, increases skin elasticity, and visibly improves skin texture3
[1]Don’t get your oil soluble Vitamin C mixed up!. (2017).
[2] Stamford, N. (2012). Stability, transdermal penetration, and cutaneous effects of ascorbic acid and its derivatives. Journal Of Cosmetic Dermatology11(4), 310-317. doi: 10.1111/jocd.12006
[3] Pilot evaluation of safety, efficacy, and tolerability of a new topical formulation for facial hyperpigmentation, combining ascorbyl tetraisopalmitate and crosslinked resilient hyaluronic acid. (2018). Journal Of The American Academy Of Dermatology, 79(3), AB222. doi: 10.1016/j.jaad.2018.05.889
[4] Ochiai, Y., Kaburagi, S., Obayashi, K., Ujiie, N., Hashimoto, S., Okano, Y., Masaki, H., Ichihashi, M., & Sakurai, H. (2006). A new lipophilic pro-vitamin C, tetra-isopalmitoyl ascorbic acid (VC-IP), prevents UV-induced skin pigmentation through its anti-oxidative properties. Journal of dermatological science44(1), 37–44.


Products with Ascorbyl Tetraisopalmitate