Dipeptide-2

anti-wrinkle + laxity · hydrating · barrier support
by cipher skincare published: feb 3, 2025 revised: feb 16, 2026 1 min read
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why we use dipeptide-2

The Peptide for Puffy Eyes

Dipeptide-2 is a synthetic peptide formed by linking the amino acids valine and tryptophan. It is designed to mimic naturally occurring peptides in the body, contributing to vascular regulation and skin health. Dipeptide-2 is commonly incorporated into skincare formulations, particularly those targeting the delicate under-eye area, due to its proposed ability to enhance lymphatic drainage and improve microcirculation. This mechanism aims to reduce fluid retention and puffiness in the periorbital region, making it a popular ingredient in eye creams and serums.1

Clinical Efficacy of Dipeptide-2

In recent clinical studies, formulations containing Dipeptide-2 have demonstrated promising results in improving periocular skin concerns. Over a 28-day period, participants using a multi-peptide eye serum, which included Dipeptide-2, showed significant reductions in wrinkle depth and volume. Additionally, improvements were observed in skin hydration, elasticity, and firmness around the eyes. The serum was well-tolerated, with no reported adverse effects, highlighting Dipeptide-2's potential as a gentle yet effective ingredient for reducing under-eye puffiness and enhancing skin texture.1

references

  1. 1 Li F, Chen H, Chen D, et al. Clinical evidence of the efficacy and safety of a new multi-peptide anti-aging topical eye serum. J Cosmet Dermatol. 2023; 22: 3340-3346. doi:10.1111/jocd.15849 Clinical evidence of the efficacy and safety of a new multi-peptide anti-aging topical eye serum.

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