Gluconolactone

antioxidant · hydrating · exfoliating · acne-prone
by cipher skincare published: jan 26, 2020 revised: feb 18, 2026 1 min read
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why we use gluconolactone

Gentle Exfoliation + Hydration

Gluconolactone is a polyhydroxy acid (PHA) celebrated for its multifaceted skin benefits beyond gentle exfoliation. Its larger molecular structure compared to alpha hydroxy acids (AHAs) results in slower skin penetration, reducing the risk of irritation and making it suitable for sensitive skin types.1 Beyond exfoliation, gluconolactone is a potent humectant, attracting and retaining moisture to enhance skin hydration.

Equally important, gluconolactone doesn’t increase skin’s susceptibility to sunburn like AHAs, and it may help repair existing cutaneous photodamage.2 Its antioxidant properties combat free radicals, contributing to a more radiant complexion.2 PHAs are a great option for all skin types and have proven to work well on skin tones ranging from light to deep.1

A Multifunctional Active

Additionally, Gluconolactone is an effective chelating agent. Chelating agents bind to metal ions such as iron and copper, which can otherwise destabilise formulations and degrade active ingredients over time. By sequestering these metal ions, it helps maintain the stability, efficacy, and shelf life of skincare products. This property is particularly valuable in water-based formulations, where trace metals from packaging or water sources could lead to oxidation and product degradation.

references

  1. 1 Grimes PE, Green BA, Wildnauer RH, Edison BL. The use of polyhydroxy acids (PHAs) in photoaged skin. Cutis. 2004 Feb;73(2 Suppl):3-13. The use of polyhydroxy acids (PHAs) in photoaged skin.
  2. 2 Bernstein, E.F., Brown, D.B., Schwartz, M.D., Kaidbey, K. and Ksenzenko, S.M. (2004), The Polyhydroxy Acid Gluconolactone Protects Against Ultraviolet Radiation in an In Vitro Model of Cutaneous Photoaging. Dermatologic Surgery, 30: 189-196. doi:10.1111/j.1524-4725.2004.30060.x The Polyhydroxy Acid Gluconolactone Protects Against Ultraviolet Radiation in an In Vitro Model of Cutaneous Photoaging.

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