Why we use Superoxide Dismutase

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why we use superoxide dismutase

The Basics

Superoxide Dismutase (SOD) is a critical enzyme present in all living cells, serving as a primary defense against oxidative stress by catalysing the dismutation of superoxide radicals into oxygen and hydrogen peroxide. This enzymatic action is essential for maintaining cellular integrity and preventing damage induced by reactive oxygen species (ROS).¹

A Unique Mode of Action

SOD works by catalysing the conversion of superoxide radicals into molecular oxygen and hydrogen peroxide. Unlike standard antioxidants, enzymatic SOD is not depleted during this neutralisation process, allowing it to continuously protect the skin from oxidative stress.¹ This unique property makes SOD one of the most efficient and sustainable antioxidants available in skincare.

What Superoxide Dismutase can do for skin

antioxidant

In dermatological applications, SOD is esteemed for its potent antioxidant capabilities. By neutralising superoxide radicals, SOD mitigates oxidative damage to skin cells, thereby preserving skin structure and function. Research indicates that SOD can prevent the degradation of collagen fibres, a process often accelerated by oxidative stress, thus maintaining skin elasticity and reducing the appearance of fine lines and wrinkles.²

Soothing

Furthermore, SOD exhibits skin-soothing properties, which can alleviate redness and irritation. Its ability to modulate inflammatory responses supports calmer, more even-toned skin.³

Protective

Additionally, SOD enhances the skin’s resilience against environmental stressors, such as ultraviolet (UV) radiation and pollution. By bolstering the skin’s natural antioxidant defence mechanisms, SOD helps protect against visible signs of skin stress, contributing to a more vibrant and healthy complexion.³

references

1 Perry, J. J. P., Shin, D. S., Getzoff, E. D., & Tainer, J. A. (2010). The structural biochemistry of the superoxide dismutases. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 1804(2), 245–262. doi: 10.1016/j.bbapap.2009.11.004 The structural biochemistry of the superoxide dismutases.
2 Lee, M. J., Agrahari, G., Kim, H. Y., An, E. J., Chun, K. H., Kang, H., Kim, Y. S., Bang, C. W., Tak, L. J., & Kim, T. Y. (2021). Extracellular superoxide dismutase prevents skin aging by promoting collagen production through the activation of AMPK and Nrf2/HO-1 cascades. Journal of Investigative Dermatology, 141(10), 2344–2353.e7. doi: 10.1016/j.jid.2021.02.757 Extracellular superoxide dismutase prevents skin aging by promoting collagen production through the activation of AMPK and Nrf2/HO-1 cascades.
3 Zheng, M., Liu, Y., Zhang, G., Yang, Z., Xu, W., & Chen, Q. (2023). The Applications and Mechanisms of Superoxide Dismutase in Medicine, Food, and Cosmetics. Antioxidants, 12(9), 1675. doi 10.3390/antiox12091675 The Applications and Mechanisms of Superoxide Dismutase in Medicine, Food, and Cosmetics.