Why we use Oryzanol · Cipher Skincare Skip to main content

Oryzanol

overview

known as gamma oryzanol

source rice bran oil

function antioxidant, photoprotective, sebum-balancing, brightening

Gamma Oryzanol

Gamma oryzanol is a multi-functional phytosterol from rice bran oil with powerful antioxidant and anti-inflammatory abilities.1 It contains a mixture of sterols and ferulic acids that effectively combat free radicals and UV damage while slowing the progress of melanin pigmentation in the skin.2 Oryzanol can also stabalise oils from oxidation and moisturise dry skin by stimulating the sebaceous glands to balance natural oil production.3

Oryzanol inhibits melanin synthesis in two ways: by inhibiting tyrosinase enzyme activity and by reducing the expression of microphthalmia-associated transcription factor (MITF).2 MITF controls the expression of various genes that are essential for melanin synthesis in melanocytes, so suppressing it results in a lightened skin tone.4

references

[1] Saenjum, Chalermpong & Chaiyasut, Chaiyavat & Chansakaow, Sunee & Suttajit, Maitree & Sirithunyalug, Busaban. (2012). Antioxidant and anti-inflammatory activities of gamma-oryzanol rich extracts from Thai purple rice bran. Journal of Medicinal Plants Research. 6.

[2] Jun H., Lee J., Cho B., Seo W., Kang H., Kim D., Cho K., and Lee. (2012), Dual Inhibition of γ-Oryzanol on Cellular Melanogenesis: Inhibition of Tyrosinase Activity and Reduction of Melanogenic Gene Expression by a Protein Kinase A-Dependent Mechanism. J. Nat. Prod. 75, 10, 1706-1711. doi:10.1021/np300250m

[3] Ueda, H., Hayakawa, R., Hoshino, S. and Kobayashi, M. (1976), THE EFFECT OF TOPICALLY APPLIED γ‐ORYZANOL ON SEBACEOUS GLANDS. The Journal of Dermatology, 3: 19-24. doi:10.1111/j.1346-8138.1976.tb00965.x

[4] Wikipedia contributors. (2019, December 18). Microphthalmia-associated transcription factor. In Wikipedia, The Free Encyclopedia. Retrieved 01:02, January 23, 2020, from https://en.wikipedia.org/w/index.php?title=Microphthalmia-associated_transcription_factor&oldid=931290860

Explore More

Xylitylglucoside amino acid skin hydration natural moisturizing factors serine Histidine

Serine

Serine is an amino acid. It supports healthy skin function and helps ensure optimal hydration. Amino acids are building blocks of collagen and…

Propanediol

Propanediol functions as an emollient, humectant, and solvent and is derived from corn. It is considered a more skin-friendly alternative to propylene glycol.

Gluconolactone

Gluconolactone is a polyhydroxy acid (PHA) with more talents than exfoliation alone. Gentle and hydrating, it can be great for everyday use. Like…
Stearyl Glycyrrhetinate glycyrrhetinic acid glycyrrhiza glabra licorice root extract glabridin

Glycyrrhiza Glabra (Licorice) Root Extract

A whole-root licorice extract standardized for its anti-inflammatory glycyrrhizinic acid content. It is great for sensitive skin and boasts antioxidant, brightening, and skin…